We've published..

Last updated June 2024

1. Mokbel, AY, Burns MP, Main BS (2024) The contribution of the meningeal immune interface to neuroinflammation in traumatic brain injury. Journal of Neuroinflammation 21: 135 doi.org/10.1186/s12974-024-03122-7

2. Chapman DP, Powers SD, ^Vicini S, ^Ryan TJ, ^Burns MP (^joint senior authors)(2024) Amnesia after repeated head impact is caused by impaired synaptic plasticity in the memory engram. Journal of Neuroscience 44 (8) e1560232024 doi.org/10.1523/JNEUROSCI.1560-23.2024

3. Buenaventura RG, Harvey AC, Burns MP, Main BS (2023) Traumatic brain injury induces an adaptive immune response in the meningeal transcriptome that is amplified by aging.  Frontiers in Neuroscience 17: 1210175 

doi: 10.3389/fnins.2023.1210175 

4. Romariz SAA, Main BS, Harvey AC, Longo BM, Burns MP (2023) Delayed treatment with ceftriaxone reverses the enhanced sensitivity of TBI mice to chemically-induced seizures. PLoS One 18(7): e0288363. https://doi.org/10.1371/journal.pone.0288363

5. Chapman DP, Vicni S, Burns MP, Evans R (2023) Single Neuron Modeling Identifies Potassium Channel Modulation as Potential Target for Repetitive head Impacts. Neuroinformatics https://pubmed.ncbi.nlm.nih.gov/37294503/.
   (Click here for data and code)

6. Buenaventura RG, Harvey AC, Burns MP, Main BS (2022) Sequential Isolation of Microglia and Astrocytes from Young and Aged Adult Mouse Brains for Downstream Transcriptomic Analysis. Methods and Protocols 5: 77 https://doi.org/10.3390/mps5050077

7. Korthas HT, Main BS, Harvey AC, Buenaventura RG, Wicker E, Forcelli PA, Burns MP (2022) The effect of traumatic brain injury on sleep architecture and circadian rhythms in mice - a comparison of high-frequency head impact and controlled cortical injury. Biology 11:1031 https://doi.org/10.3390/biology11071031

8. Chapman DP* & Sloley SS* (*joint first authors), Caccavano A, Vicini S^ & Burns MP^ (^joint senior authors) (2022) High-frequency head impact disrupts hippocampal neural ensemble dynamics. Frontiers Cellular Neuroscience Doi:=10.3389/fncel.2021.763423

9. Sloley S.S.* & Main B.S.* (*joint first authors), Winston C.N., Harvey A.C., Kaganovich A., Korthas H.T., Caccavan  A., Zapple D., Wu J-Y, Partridge J.G., Cookson M.R.* & Vicini S.* & Burns M.P.* (*joint senior authors) (2021) High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment. Nature Communications, 12, 2613. https://www.nature.com/articles/s41467-021-22744-6 

10. Huynh LM, Burns MP, Taub DD, Blackman MR, Zhou J (2020) Chronic neurobehavioral impairments and decreased hippocampal expression of genes important for brain glucose utilization in a mouse model of mild TBI. Front Endocrinol doi: 10.3389/fendo.2020.556380

11. Neckel ND, Dai HN, Burns MP. (2020) A novel multidimensional analysis of rodent gait reveals the compensation strategies employed during spontaneous recovery from spinal cord and traumatic brain injury. J Neurotrauma. 37:517-527 PubMed

12. Lee JS, Lee Y, André EA, Lee KJ, Nguyen T, Feng Y, Jia N, Harris BT, Burns MP, Pak DTS (2019) Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer's disease model mice. PLoS One. 2019 Jul 15;14(7):e0219691

13. Main BS, Villapol S, Sloley SS, Barton DJ, Parsadanian M, Agbaegbu C, Stefos K, McCann MS, Washington PM, Rodriguez OC, Burns MP (2018) Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury. Molecular Neurodegeneration 13(1):17. doi: 10.1186/s13024-018-0249-5

14. Treangen TJ, Wagner J, Burns MP,* Villapol S.* (*joint senior authors) (2018) Traumatic brain injury in mice induces acute bacterial dysbiosis within the fecal microbiome. Front Immunol. 2018 Nov 27;9:2757. doi: 10.3389/fimmu.2018.02757

15. Fe Lanfranco M, Loane DJ, Mocchetti I, Burns MP, Villapol S. (2018) Glial- and Neuronal-Specific Expression of CCL5 mRNA in the Rat Brain. Front. Neuroanat. DOI=10.3389/fnana.2017.00137 

16. Fe Lanfranco M, Loane DJ, Mocchetti I, Burns MP, Villapol S. (2017) Combination of Fluorescent in situ Hybridization (FISH) and Immunofluorescence Imaging for Detection of Cytokine Expression in Microglia/Macrophage Cells Bio Protoc. 7(22). pii: e2608 https://doi.org/10.21769/BioProtoc.2608

17. Zhou J, Burns MP, Huynh L, Villapol S, Taub DD, Saavedra JM, Blackman MR (2017). Temporal Changes in Cortical and Hippocampal Expression of Genes Important for Brain Glucose Metabolism Following Controlled Cortical Impact Injury in Mice. Front Endocrinol 8:231 https://doi.org/10.3389/fendo.2020.556380

18. Villapol S, Loane DJ, and Burns MP (2017) Sexual dimorphism in the inflammatory response to traumatic brain injury. Glia 65: 1423-1438 PubMed

19. Neustadtl AL, Winston CN, Parsadanian M, Main BS, Villapol S, Burns MP (2017) Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity. Neuroreport 28: 618-62

20. Main BS, Sloley SS, Villapol S, Zapple DN, Burns MP (2017) A mouse model of single and repetitive brain injury. JoVE (124), e55713, doi:10.3791/55713

21. Barrett JP, Henry RJ, Villapol S, Stoica BA, Kumar A, Burns MP, Faden AI, Loane DJ (2017) NOX2 deficiency alters macrophage phenotype through and IL-10/STAT3 dependent mechansism: implications for traumatic brain injury. J Neuroinflammation 14: 6

22. Heyburn L., Hebron M.L., Smith J., Winston C., Bechara J., Li Z., Lonskaya I., Burns M.P., Harris B., and Moussa C.E. (2016) Tyrosine kinase inhibition reverses TDP-43 effects on synaptic protein expression, astrocytic function and amino acid dis-homeostasis. J Neurochem 139: 610-623

23. Washington, P.M. and Burns M.P. (2016) The effect of the APOE4 gene on accumulation of A40 after brain injury cannot be reversed by increasing apoE4 protein. J. Neuropath, Exp. Neurol. 75: 770-778

24. Winston, C.N., Noel, A., Neustadtl, A., Parsadanian, M., Barton, D., Chellappa, D., Wilkins, T.E., Alikhani, A.D., Zapple, D.N., Villapol, S., Planel, E. and Burns M.P. (2016) Dendritic spine loss and chornic white matter inflammation in a mouse model of highly repetitive head trauma. Am. J. Pathol. 186: 552-567

25. Washington, P.M., Villapol, S. and Burns M.P. (2016) Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurological disease, or should they be classified together as traumatic encephalopathy? Exp. Neurol. 275:381-388

26. Kraus, M.F. and Burns, M.P. (2015) Gabapentin in the management of postconcussion symptoms: Rationale for use and case series. International Neurotrauma Letter, Issue 38.

27. Washington, P.M., Morffy, N. Parsadanian, M., Zapple, D.N. and Burns M.P. (2014) Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer’s disease mouse model. J Neurotrauma 31:125-134

28. Pajoohesh-Ganji A., Burns M.P., Pal-Ghosh S., Tadvalkar G., Hokenbury N.G., Stepp M.A., Faden A.I. (2014) Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury. Brain Res. 560:73-82

29. Winston, C.N., Chellappa, D., Wilkins, T., Barton, D.J., Washington, P.M., Loane, D.J. Zapple, D.N. and Burns M.P. (2013) Controlled cortical impact results in an extensive loss of dendritic spines that is not mediated by injury-induced amyloid-beta accumulation. J Neurotrauma 30:1966-1972

30. Rodriguez G.A., Burns M.P., Weeber E.J., Rebeck G.W. (2013) Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex. Learn Mem 20:256-266

31. Kumar A., Stoica B.A., Sabirzhanov B., Burns M.P., Faden A.I., Loane D.J. (2013) Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states. Neurobiol Disease 34:1397-1411

32. Washington, PM, Forcelli, PA, Wilkins, T., Zapple, D., Parsadanian, M. and Burns, M.P. (2012) The Effect of Injury Severity on Behavior: A phenotypic study of cognitive and emotional deficits after mild, moderate and severe controlled cortical impact injury in mice. J Neurotrauma 29: 2283-2296

33. Burns M.P. (2012) Traumatic Brain Injury and the Development of Alzheimer's Disease: Risk Factors, Diagnosis, and Treatment Strategies. In: Alzheimer's Disease: Targets for New Clinical, Diagnostic and Therapeutic Strategies Edited by: Alan Rudolph and Renee Wegryzn. CRC Press, New York. pp249-269

34. Olmos-Serrano, J.L., Corbin, J.G. and Burns, M.P. (2011) The GABA(A) Receptor Agonist THIP Ameliorates Specific Behavioral Deficits in the Mouse Model of Fragile X Syndrome. Dev Neurosci 33, 335-343. 

35. Loane, D.J., Washington, P.M., Vardanian, L., Pocivavsek, A., Hoe, H.S., Duff, K.E., Cernak, I, Rebeck, G.W., Faden, A.I. and Burns, M.P. (2011) Modulation of ABCA1 by an LXR agonist reduces beta-amyloid levels and improves outcome after traumatic brain injury. J Neurotrauma. 28:225

36. Burns, M.P. and Rebeck, G.W.(2010) Intracellular cholesterol homeostasis and amyloid precursor protein processing. Biochem Biophysica Acta Molecular and Cell Biology of Lipids. 1801:853-859

37. Noble, W and Burns, M.P. (2010) Challenges in Neurodegeneration Research. Frontiers in Psychiatry 1(7):1-2

38. Cartegena, C.M., Burns, M.P. and Rebeck G.W. (2010) 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury. Brain Research. 319:1-12

39. Minami, S.S, Sung, Y.M., Dumanis, S.B., Chi, S.H., Burns, M.P., Ann, E.J., Suzuki, T., Turner, R.S., Park, H-S, Pak, D.T.S, Rebeck, G.W. and Hoe, H.S. (2010) X11alpha and Reelin regulate ApoEr2 trafficking and cell movement. FASEB J. 24:58-69 

40. Loane, D.J., Pocivavsek, A., Moussa, C.E-H., Thompson, R., Matsuoka, Y., Faden, A.I., Rebeck, G.W., and Burns, M.P. (2009) Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nature Medicine. 15:377-379

41. Burns, M.P., Zhang, L., Rebeck, G.W., Querfurth, H.W. and Moussa, C.E-H. (2009) Parkin promotes intracellular Abeta1-42 clearance. Hum Mol Gen. 18:3206-3216

42. Pocivavsek, A., Burns, M.P. and Rebeck, G.W. (2009) Low-density lipoprotein receptors regulate microglial inflammation through C-Jun N-terminal kinase. Glia. 57:444-453

43. Cartagena, C.M., Ahmed, F., Burns, M.P., Pajoohesh-Ganji, A., Pak, D.T., Faden, A.I. and Rebeck, G.W. (2008) Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain. J. Neurotrauma. 25:1087-1098

44. Eckert, G.P., Vardanian, L., Rebeck G.W. and Burns, M.P. (2007) Regulation of central nervous system cholesterol homeostasis by the liver X receptor agonist  TO-901317. Neurosci Lett. 423: 47-52 

45. Czech, C.* & Burns, M.P.* (joint first author), Vardanian, L., Augustine, A., Jacobsen, H., Baumann, K. and Rebeck G.W. (2007) Cholesterol independent effect of LXR agonist TO-901317 on gamma-secretase. J Neurochem. 101: 929-936 

46. Hoe, H.S., Cooper, M., Burns, M.P., Lewis, P.A., van der Brug, M., Chakraborty, G., Cartegena, C., Pak, D.T.S., Cookson, M.R., Rebeck., G.W. (2007) The metalloprotease inhibitor TIMP-3 regulates APP and ApoE receptor proteolysis. J. Neurosci. 27: 10895-10905

47. Burns, M.P., Vardanian, L., Pajoohesh-Ganji, A., Wang L., Cooper M., Harris, D.C., Duff, K. and Rebeck G.W. (2006) The effects of ABCA1 on cholesterol efflux and A levels in vitro and in vivo. J Neurochem. 98: 792-800

48. Burns, M., Igbavboa, U., Wang, L., Wood, G.W. and Duff, K. (2006) Cholesterol distribution, not total levels, correlate with altered amyloid precursor protein processing in statin treated mice. NeuroMolecular Medicine. 8:319-328. 

49. Noble, W.* & Planel, E.* (*joint first author), Zehr, C., Olm, V., Meyerson, J., Suleman, F., Gaynor, K., Wang, L., LaFrancois, J., Feinstein, B., Burns, M., Krishnamurthy, P., Wen, Y., Bhat, R., Lewis, J., Dickson, D. and Duff, K. (2005) Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci USA. 102: 6990-6995

50. Burns, M.P. and Duff, K. (2004) Brains on steroids resists neurodegeneration, 2004. Nature Medicine 10: 675-676

51. Harkin, A, Connor, T.J., Burns M.P. and Kelly, J.P. (2004) Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swim test, 2004. Eur. Neuropsychopharmacol. 14: 274-281

52. Burns, M., Gaynor, K., Olm, V., Mercken, M., LaFrancois, J., Wang, L., Mathews, P.M., Noble, W., Matsuoka, Y. and Duff, K. (2003) Presenilin redistribution associated with aberrant cholesterol transport enhances -amyloid production in vivo. J Neurosci. 23: 5645-5649

53. Noble, W., Olm, V., Takata, K., Casey, E., O, M., Meyerson, J., Gaynor, K., LaFrancois, J., Wang, L., Kondo, T., Davies, P., Burns, M., Veeranna, Nixon, R., Dickson, D., Matsuoka, Y., Ahlijanian, M., Lau, LF., Duff, K. (2003) CDK5 is a key factor in tau aggregation and tangle formation in vivo. Neuron 38:555-565

54. Burns, M.P., Noble, W.J., Olm, V., Gaynor, K., Casey, L. and Duff, K.E. (2003) Co-localization of cholesterol, apolipoprotein E and fibrillar A-beta in amyloid plaques. Mol Brain Res. 110: 119-25

55. Burns, M. and Duff, K. Intracellular cholesterol homeostasis and Alzheimer's disease (2003). In: Alzheimer's disease and related disorders: Research Advances; Iqbal, K. and Winblad, B. (eds)  Ana. Aslan Intl. Acad. Aging, Bucharest, Romania. pp: 559-567

56. Burns, M. and Duff, K.E. (2003) Use of in vivo models to study the role of cholesterol in the etiology of Alzheimer's disease. Neurochem Res. 28: 979-86.

57. Burns, M. and Duff, K.E. (2003) Cholesterol in Alzheimer's disease and tauopathy. Ann NY Acad Sci. 977: 367-376