Publications

Last updated August 2017

Villapol S, Loane DJ, and Burns MP (2017) Sexual dimorphism in the inflammatory response to traumatic brain injury. Glia 65: 1423-1438

Neustadtl AL, Winston CN, Parsadanian M, Main BS, Villapol S, Burns MP (2017) Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity. Neuroreport 28: 618-624

Main BS, Sloley SS, Villapol S, Zapple DN, Burns MP (2017) A mouse model of single and repetitive brain injury. JoVE (124), e55713, doi:10.3791/55713

Barrett JP, Henry RJ, Villapol S, Stoica BA, Kumar A, Burns MP, Faden AI, Loane DJ (2017) NOX2 deficiency alters macrophage phenotype through and IL-10/STAT3 dependent mechansism: implications for traumatic brain injury. J Neuroinflammation 14: 65

Heyburn L., Hebron M.L., Smith J., Winston C., Bechara J., Li Z., Lonskaya I., Burns M.P., Harris B., and Moussa C.E. (2016) Tyrosine kinase inhibition reverses TDP-43 effects on synaptic protein expression, astrocytic function and amino acid dis-homeostasis. J Neurochem 139: 610-623

Washington, P.M. and Burns M.P. (2016) The effect of the APOE4 gene on accumulation of A40 after brain injury cannot be reversed by increasing apoE4 protein. J. Neuropath, Exp. Neurol. 75: 770-778

Winston, C.N., Noel, A., Neustadtl, A., Parsadanian, M., Barton, D., Chellappa, D., Wilkins, T.E., Alikhani, A.D., Zapple, D.N., Villapol, S., Planel, E. and Burns M.P. (2016) Dendritic spine loss and chornic white matter inflammation in a mouse model of highly repetitive head trauma. Am. J. Pathol. 186: 552-567

Washington, P.M., Villapol, S. and Burns M.P. (2016) Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurological disease, or should they be classified together as traumatic encephalopathy? Exp. Neurol. 275:381-388

Kraus, M.F. and Burns, M.P. (2015) Gabapentin in the management of postconcussion symptoms: Rationale for use and case series. International Neurotrauma Letter, Issue 38.

Washington, P.M., Morffy, N. Parsadanian, M., Zapple, D.N. and Burns M.P. (2014) Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer’s disease mouse model. J Neurotrauma 31:125-134

Pajoohesh-Ganji A., Burns M.P., Pal-Ghosh S., Tadvalkar G., Hokenbury N.G., Stepp M.A., Faden A.I. (2014) Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury. Brain Res. 560:73-82

Washington, P.M., Morffy, N. Parsadanian, M., Zapple, D.N. and Burns M.P. (2014) Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer's disease mouse model. J Neurotrauma 31:125-134

Winston, C.N., Chellappa, D., Wilkins, T., Barton, D.J., Washington, P.M., Loane, D.J. Zapple, D.N. and Burns M.P. (2013) Controlled cortical impact results in an extensive loss of dendritic spines that is not mediated by injury-induced amyloid-beta accumulation. J Neurotrauma 30:1966-1972

Rodriguez G.A., Burns M.P., Weeber E.J., Rebeck G.W. (2013) Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex. Learn Mem 20:256-266

Kumar A., Stoica B.A., Sabirzhanov B., Burns M.P., Faden A.I., Loane D.J. (2013) Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states. Neurobiol Disease 34:1397-1411

Washington, PM, Forcelli, PA, Wilkins, T., Zapple, D., Parsadanian, M. and Burns, M.P. (2012) The Effect of Injury Severity on Behavior: A phenotypic study of cognitive and emotional deficits after mild, moderate and severe controlled cortical impact injury in mice. J Neurotrauma 29: 2283-2296

Olmos-Serrano, J.L., Corbin, J.G. and Burns, M.P. (2011) The GABA(A) Receptor Agonist THIP Ameliorates Specific Behavioral Deficits in the Mouse Model of Fragile X Syndrome. Dev Neurosci 33, 335-343.

Loane, D.J., Washington, P.M., Vardanian, L., Pocivavsek, A., Hoe, H.S., Duff, K.E., Cernak, I, Rebeck, G.W., Faden, A.I. and Burns, M.P. (2011) Modulation of ABCA1 by an LXR agonist reduces beta-amyloid levels and improves outcome after traumatic brain injury. J Neurotrauma. 28:225

Burns, M.P. and Rebeck, G.W.(2010) Intracellular cholesterol homeostasis and amyloid precursor protein processing. Biochem Biophysica Acta Molecular and Cell Biology of Lipids. 1801:853-859

Noble, W and Burns, M.P. (2010) Challenges in Neurodegeneration Research. Frontiers in Psychiatry 1(7):1-2

Cartegena, C.M., Burns, M.P. and Rebeck G.W. (2010) 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury. Brain Research. 319:1-12

Minami, S.S, Sung, Y.M., Dumanis, S.B., Chi, S.H., Burns, M.P., Ann, E.J., Suzuki, T., Turner, R.S., Park, H-S, Pak, D.T.S, Rebeck, G.W. and Hoe, H.S. (2010) X11alpha and Reelin regulate ApoEr2 trafficking and cell movement. FASEB J. 24:58-69

Loane, D.J., Pocivavsek, A., Moussa, C.E-H., Thompson, R., Matsuoka, Y., Faden, A.I., Rebeck, G.W., and Burns, M.P. (2009) Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nature Medicine. 15:377-379

Burns, M.P., Zhang, L., Rebeck, G.W., Querfurth, H.W. and Moussa, C.E-H. (2009) Parkin promotes intracellular Abeta1-42 clearance. Hum Mol Gen. 18:3206-3216

Pocivavsek, A., Burns, M.P. and Rebeck, G.W. (2009) Low-density lipoprotein receptors regulate microglial inflammation through C-Jun N-terminal kinase. Glia. 57:444-453

Cartagena, C.M., Ahmed, F., Burns, M.P., Pajoohesh-Ganji, A., Pak, D.T., Faden, A.I. and Rebeck, G.W. (2008) Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain. J. Neurotrauma. 25:1087-1098

Eckert, G.P., Vardanian, L., Rebeck G.W. and Burns, M.P. (2007) Regulation of central nervous system cholesterol homeostasis by the liver X receptor agonist TO-901317. Neurosci Lett. 423: 47-52

Czech, C., Burns, M.P. (joint first author), Vardanian, L., Augustine, A., Jacobsen, H., Baumann, K. and Rebeck G.W. (2007) Cholesterol independent effect of LXR agonist TO-901317 on gamma-secretase. J Neurochem. 101: 929-936

Hoe, H.S., Cooper, M., Burns, M.P., Lewis, P.A., van der Brug, M., Chakraborty, G., Cartegena, C., Pak, D.T.S., Cookson, M.R., Rebeck., G.W. (2007) The metalloprotease inhibitor TIMP-3 regulates APP and ApoE receptor proteolysis. J. Neurosci. 27: 10895-10905

Burns, M.P., Vardanian, L., Pajoohesh-Ganji, A., Wang L., Cooper M., Harris, D.C., Duff, K. and Rebeck G.W. (2006) The effects of ABCA1 on cholesterol efflux and A levels in vitro and in vivo. J Neurochem. 98: 792-800

Burns, M., Igbavboa, U., Wang, L., Wood, G.W. and Duff, K. (2006) Cholesterol distribution, not total levels, correlate with altered amyloid precursor protein processing in statin treated mice. NeuroMolecular Medicine. 8:319-328.

Noble, W., Planel, E., Zehr, C., Olm, V., Meyerson, J., Suleman, F., Gaynor, K., Wang, L., LaFrancois, J., Feinstein, B., Burns, M., Krishnamurthy, P., Wen, Y., Bhat, R., Lewis, J., Dickson, D. and Duff, K. (2005) Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci USA. 102: 6990-6995

Burns, M.P. and Duff, K. (2004) Brains on steroids resists neurodegeneration, 2004. Nature Medicine 10: 675-676

Harkin, A, Connor, T.J., Burns M.P. and Kelly, J.P. (2004) Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swim test, 2004. Eur. Neuropsychopharmacol. 14: 274-281

Burns, M., Gaynor, K., Olm, V., Mercken, M., LaFrancois, J., Wang, L., Mathews, P.M., Noble, W., Matsuoka, Y. and Duff, K. (2003) Presenilin redistribution associated with aberrant cholesterol transport enhances -amyloid production in vivo. J Neurosci. 23: 5645-5649

Noble, W., Olm, V., Takata, K., Casey, E., O, M., Meyerson, J., Gaynor, K., LaFrancois, J., Wang, L., Kondo, T., Davies, P., Burns, M., Veeranna, Nixon, R., Dickson, D., Matsuoka, Y., Ahlijanian, M., Lau, LF., Duff, K. (2003) CDK5 is a key factor in tau aggregation and tangle formation in vivo. Neuron 38:555-565

Burns, M.P., Noble, W.J., Olm, V., Gaynor, K., Casey, L. and Duff, K.E. (2003) Co-localization of cholesterol, apolipoprotein E and fibrillar A-beta in amyloid plaques. Mol Brain Res. 110: 119-25

Burns, M. and Duff, K.E. (2003) Use of in vivo models to study the role of cholesterol in the etiology of Alzheimer's disease. Neurochem Res. 28: 979-86.

Burns, M. and Duff, K.E. (2003) Cholesterol in Alzheimer's disease and tauopathy. Ann NY Acad Sci. 977: 367-376

BOOK CHAPTERS

Burns M.P. (2012) Traumatic Brain Injury and the Development of Alzheimer's Disease: Risk Factors, Diagnosis, and Treatment Strategies. In: Alzheimer's Disease: Targets for New Clinical, Diagnostic and Therapeutic Strategies Edited by: Alan Rudolph and Renee Wegryzn. CRC Press, New York. pp249-269

Burns, M. and Duff, K. Intracellular cholesterol homeostasis and Alzheimer's disease (2003). In: Alzheimer's disease and related disorders: Research Advances; Iqbal, K. and Winblad, B. (eds) Ana. Aslan Intl. Acad. Aging, Bucharest, Romania. pp: 559-567